Today MicroMGx, Inc. announces it has initiated a collaboration with Elanco Animal Health Inc to discover novel animal health products based on or derived from microorganisms. Under the agreement, MicroMGx will use its MGx technology platform to profile microorganisms that have the potential to boost animal health and prevent diseases.
“Partnering with MicroMGx fits our mission to develop new tools and products to manage the animal microbiome,” said Kristin Bloink, vice president, Global Research & Exploratory Development at Elanco. “Their unique approach to mining value from microorganisms opens avenues that will help us create innovative new products.”MicroMGx specializes in the discovery of natural products from microorganisms that can be used as active ingredients in products for pharmaceuticals, agriculture, and animal health. MicroMGx’s flagship technology is the metabologenomics (MGx) platform, which uses genomics and metabolomics to prioritize microorganisms with commercially useful capabilities.
Probiotics and natural products derived from microorganisms represent a significant share of the $46.8B animal health industry. Natural products are used in diverse products in the animal health industry including feed additives, antibiotics, and other anti-infectives. Probiotic products include dietary supplements and feed additive products.
Jack Kloeber, PhD, CEO of MicroMGx, remarked “This is our first strategic partnership in the animal health space. We are incredibly excited to be working with Elanco and to have this opportunity to demonstrate the potential of our platform and technology to help improve the lives of animals.”
Actinobacteria is a phylum of Gram-positive bacteria with high guanine and cytosine content in their DNA. Although understood primarily as soil bacteria, they might be more abundant in freshwaters. Considered to be one of the most prolific producers of natural products.
Bacteria are single celled microbes. The cell structure is simpler than that of other organisms as there is no nucleus or membrane bound organelles. Instead their control centre containing the genetic information is contained in a single loop of DNA.
A biological system is a complex network of biologically relevant entities. As biological organization spans several scales, examples of biological systems are populations of organisms, or on the organ- and tissue scale in mammals and other animals, the circulatory system, the respiratory system, the nervous system, etc.
On the micro- to the nanoscopic scale, examples of biological systems are cells, organelles, macromolecular complexes and regulatory pathways.
High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material.
Mass Spectrometry (MS) is an analytical chemistry technique that helps identify the amount and type of chemicals present in a sample by measuring the mass-to-charge ratio and abundance of gas-phase ions.
Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones).