The leading agriscience companies are looking to innovation and natural products discovery for a more effective and efficient way to increase new product development, product effectiveness and growth.
Genome mining has emerged in the past decade as a key technology to explore and exploit natural product diversity and the success that it brings for new product development.
Key to this success is the fact that genes encoding natural product biosynthetic pathways are usually clustered together on the chromosome. These biosynthetic gene clusters (BGCs) can be readily identified in a genome sequence. Moreover, in many cases, the chemical structures of their products can be predicted to a certain extent, based on the analysis and biosynthetic logic of the enzymes encoded in a BGC and their similarity to known counterparts. Read article: A computational framework to explore large-scale biosynthetic diversity
By following nature and using an “untargeted (for novelty)” and “massively parallel (for efficiency)” approach with natural products discovery, instead of engineering or using synthetics, MicroMGx delivers more affordable natural products discovery for accelerated innovation.
Actinobacteria is a phylum of Gram-positive bacteria with high guanine and cytosine content in their DNA. Although understood primarily as soil bacteria, they might be more abundant in freshwaters. Considered to be one of the most prolific producers of natural products.
Bacteria are single celled microbes. The cell structure is simpler than that of other organisms as there is no nucleus or membrane bound organelles. Instead their control centre containing the genetic information is contained in a single loop of DNA.
A biological system is a complex network of biologically relevant entities. As biological organization spans several scales, examples of biological systems are populations of organisms, or on the organ- and tissue scale in mammals and other animals, the circulatory system, the respiratory system, the nervous system, etc.
On the micro- to the nanoscopic scale, examples of biological systems are cells, organelles, macromolecular complexes and regulatory pathways.
High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material.
Mass Spectrometry (MS) is an analytical chemistry technique that helps identify the amount and type of chemicals present in a sample by measuring the mass-to-charge ratio and abundance of gas-phase ions.
Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones).